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Published on: 13 Oct 2017 by hiepnv1902

Severe epilepsy and circadian rhythm protein linked

Severe epilepsy and circadian rhythm protein linked

Researchers probing the brain tissue of people with severe forms of epilepsy make a surprising breakthrough: a protein involved in circadian rhythms, called CLOCK, may play a role.

Epilepsy is a relatively common brain disorder that causes seizures. It affects around 1.2 percent of people in the United States, And to date, it is not curable.

There are drugs available to treat the condition, but side effects can be significant And not all cases of epilepsy respond well.

Tham khao:

Although certain genetic mutations have been identified that are responsible for inherited forms of epilepsy, these only account for a minority of cases. In most cases, the exact causes are unknown.

Most individuals with epilepsy have focal epilepsy, meaning that the seizures arise in a specific one part of the brain where the tissue is abnormal. To date, the reasons why these sick regions of tissue become epileptogenic are not understood.

In severe cases of focal epilepsy that do not respond to treatment, the brain area responsible for the seizures may be surgically Removed. And recently, a team examined these excised pieces of tissue, looking for random differences that might shed Definitely more light Above the condition.

Inspecting epileptogenic brain tissue

The corresponding author for the study was Dr. Judy Liu, an assistant professor of neurology at Brown University in Providence, RI. The results are published this week in the journal Neuron.

Dr. Liu studied brain tissue from eight patients with either focal cortical dysplasia or tuberous sclerosis complex.

Focal cortical dysplasia is one of the most common causes of epilepsy that does not respond to treatment. Tuberous sclerosis is a Individual genetic condition that causes non-cancerous tumors to develop. If these tumors develop in the brain, it can cause epilepsy.

when brain tissue is nockouted to treat epilepsy, healthy tissue is sometimes nockouted to get access to the area of interest. For this study, these healthy sections were used as a control.

Dr. Liu and her colleagues analyzed the tissue's transcriptome, or a survey of the messenger RNA (mRNA) in Any given population of cells. This tells scientists which portions of the DNA are being expressed and producing proteins.

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